In an article in the February 1994 issue of Mental Retardation, Wolfensberger briefly remarked on the neurotoxic, and health-and life-destroying, effects of prescription psychoactive drugs. In the October 1994 issue, Levitas et al. strongly questioned that assertion, at least as long as the drugs are not used “indiscriminately,” and questioned the publication of such controversial statements without documentation. In this article, Wolfensberger provides extensive elaboration, analysis, and documentation of his original assertion.